WASF1
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1: 1000approx. 1: 5000. IHC: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
scar1 antibody, wave1 antibody, ATRANGAP2 antibody, ATSCAR1 antibody, SCAR1 antibody, T14G11.27 antibody, T14G11_27 antibody, WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY VERPROLIN HOMOLOGOUS PROTEIN 1 antibody, wave antibody, WAVE antibody, WAVE1 antibody, AI195380 antibody, AI838537 antibody, Scar antibody, WAVE-1 antibody, WAS protein family member 1 S homeolog antibody, SCAR family protein antibody, WAS protein family member 1 antibody, WAS protein family, member 1 antibody, wasf1.S antibody, AT2G34150 antibody, wasf1 antibody, WASF1 antibody, Wasf1 antibody
Background
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes.Synonyms: KIAA0269, SCAR1, Verprolin homology domain-containing protein 1, WASP family protein member 1, WAVE-1, Wiskott-Aldrich syndrome protein family member 1