IFNAR1 antibody

Catalog No. ABIN272114

The Rabbit Polyclonal anti-IFNAR1 antibody is suitable to detect IFNAR1 in samples from Human and Mouse. It has been validated for IF and IHC (p).

Quick Overview for IFNAR1 antibody (ABIN272114)

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR1 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IFNAR1 Antibody

Specificity: This antibody detects endogenous levels of IFN-α/βRα protein. (region surrounding Leu461)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFNAR1

Background: The type I interferons, IFN-α and IFN-β, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-α and IFN-β appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-γ) binds to a distinct receptor. This distinct receptor, IFN-αR, is only weakly responsive to type I interferons, in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-α subtypes. IFN-α/βR is expressed as two alternatively spliced transcripts, designated IFN-α/βRα (IFN-α/βR1) and IFN-α/βRβ (IFN- α/βR2), both of which are involved in signal transduction and ligand binding.Synonyms: CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Interferon-alpha/beta receptor alpha chain, Type I interferon receptor 1

Gene ID: 3454

NCBI Accession: NP_000620

UniProt: P17181

Pathways: JAK-STAT Signaling, Hepatitis C