IFNAR1 antibody (AA 162-188)

Catalog No. ABIN652490

There is 1 publication for this product available. The Rabbit Polyclonal anti-IFNAR1 antibody is suitable to detect IFNAR1 in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for IFNAR1 antibody (AA 162-188) (ABIN652490)

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFNAR1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21945

Product Details anti-IFNAR1 Antibody

Binding Specificity: AA 162-188

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IFNAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-188 amino acids of human IFNAR1.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P-Leica: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-IFNAR1 antibody (ABIN652490)

Dendrou, Cortes, Shipman, Evans, Attfield, Jostins, Barber, Kaur, Kuttikkatte, Leach, Desel, Faergeman, Cheeseman, Neville, Sawcer, Compston, Johnson, Everett, Bell, Karpe, Ultsch, Eigenbrot, McVean et al.: "Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. ..." in: Science translational medicine, Vol. 8, Issue 363, pp. 363ra149, (2017) (PubMed).

Target Details for IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Alternative Name: IFNAR1

Background: IFNAR1 is the receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha-and beta-subunits themselves.

Molecular Weight: 63525

Gene ID: 3454

NCBI Accession: NP_000620

UniProt: P17181

Pathways: JAK-STAT Signaling, Hepatitis C