KLF11 antibody

Catalog No. ABIN272134

Product Details anti-KLF11 Antibody

Target: KLF11 (Kruppel-Like Factor 11 (KLF11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLF11 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of TIEG2 protein. (region surrounding Phe6)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for KLF11

Target: KLF11 (Kruppel-Like Factor 11 (KLF11))

Alternative Name: KLF11 / TIEG2 (KLF11 Products)

Synonyms: FKLF antibody, FKLF1 antibody, MODY7 antibody, TIEG2 antibody, Tieg3 antibody, 9830142A17 antibody, D12Ertd427e antibody, Tieg2 antibody, Tieg2b antibody, Tcfcp2l2 antibody, KLF11 antibody, klf11 antibody, si:dkey-81b15.5 antibody, tieg3 antibody, wu:fc45c07 antibody, wu:fj44b12 antibody, zgc:153255 antibody, fklf antibody, fklf1 antibody, mody7 antibody, tieg2 antibody, MGC145216 antibody, TIEG-2 antibody, zgc:154048 antibody, Kruppel like factor 11 antibody, Kruppel-like factor 11 antibody, Kruppel-like factor 11 L homeolog antibody, Kruppel-like factor 11a antibody, Krueppel-like factor 11 antibody, Kruppel-like factor 11b antibody, KLF11 antibody, Klf11 antibody, klf11.L antibody, klf11a antibody, klf11 antibody, LOC100194692 antibody, klf11b antibody

Background: Originally isolated from osteoblastic cells, the TGF-beta-inducible early gene-1 (TIEG1) is a Krupel-like zinc finger transcription factor-encoding gene which regulates cellular growth and differentiation. TIEG1 is regulated as an early response gene by TGFβ1. It is expressed in both acinar and ductular epithelial cells from exocrine pancreas and may serve as an early response gene in pancreatic cell lines. Further, overexpression of TIEG1 in TGFβ-sensitive epithelial cells induces apoptosis. TIEG1 and EGR-α are expressedfrom alternate promoters of the same gene. TIEG1 and EGR-α are both highly expressed in human fetal osteoblast cells. TIEG1 is additionally expressed at high levels in PBLs, spleen and colon, and at lower levels in thymus, small intestine, ovary, prostate and skeletal muscle. The nuclear TIEG2 protein, which shares significant homology with TIEG1, was originally isolated from globin-expressing human fetal eryth-roid cells. TIEG2 is also expressed in fetal liver. Overexpression of TIEG2 in cultured epithelial cells inhibits cellular proliferation, TIEG2 expression is upregulated by TGFβ1 and serum deprivation.Synonyms: FKLF, Krueppel-like factor 11, TGFB-inducible early growth response protein 2, TIEG-2, Transforming growth factor-beta-inducible early growth response protein 2

Molecular Weight: approx. 55 kDa

Gene ID: 8462

NCBI Accession: NP_001171187

UniProt: O14901