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NCBP1 antibody

NCBP1 Reactivity: Human, Mouse, Rat WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN272218
  • Target See all NCBP1 Antibodies
    NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
    Reactivity
    • 47
    • 31
    • 13
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 58
    • 4
    Rabbit
    Clonality
    • 61
    • 2
    Polyclonal
    Conjugate
    • 25
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This NCBP1 antibody is un-conjugated
    Application
    • 32
    • 22
    • 13
    • 13
    • 7
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects endogenous levels of CBP80 protein. (region surrounding Arg5)
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Purity
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product NCBP1 Primary Antibody
  • Application Notes
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    DO NOT FREEZE!
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
    Alternative Name
    NCBP1 (NCBP1 Products)
    Synonyms
    CBP80 antibody, CG7035 antibody, Dmel\\CG7035 antibody, EG:84H4.3 antibody, ncbp antibody, sto1 antibody, cbp80 antibody, AU014645 antibody, AW538051 antibody, NCBP antibody, Sto1 antibody, ncbp1 antibody, ABA HYPERSENSITIVE 1 antibody, ATCBP80 antibody, CAP-BINDING PROTEIN 80 antibody, ENS antibody, ENSALADA antibody, NUCLEAR CAP-BINDING PROTEIN CBP80 antibody, T10F5.8 antibody, T10F5_8 antibody, cap binding protein 80 antibody, nuclear cap binding protein subunit 1 antibody, nuclear cap binding protein subunit 1 S homeolog antibody, nuclear cap binding protein subunit 1, 80kDa antibody, nuclear cap binding protein subunit 1 L homeolog antibody, ARM repeat superfamily protein antibody, Nuclear cap-binding protein subunit 1-A antibody, Nuclear cap-binding protein subunit 1 antibody, Cbp80 antibody, ncbp1 antibody, ncbp1.S antibody, NCBP1 antibody, Ncbp1 antibody, ncbp1.L antibody, ABH1 antibody, nbp1a antibody, ncbp-1 antibody
    Background
    In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex(CBC). CBC consists of two cap binding proteins CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively. CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80. CBP also plays a role in nonsense-mediated decay(NMD), which eliminates mRNAs, which prematurely terminate translation.CBP80-bound mRNA undergoes a Synonyms: CBP80, NCBP, Nuclear cap-binding protein subunit 1
    Molecular Weight
    approx. 88 kDa
    Gene ID
    4686
    NCBI Accession
    NP_002477
    UniProt
    Q09161
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Photoperiodism, Methionine Biosynthetic Process
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