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DCP1A antibody

DCP1A Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN272254
  • Target See all DCP1A Antibodies
    DCP1A (DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A))
    Reactivity
    • 65
    • 19
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 57
    • 7
    • 1
    Rabbit
    Clonality
    • 52
    • 13
    Polyclonal
    Conjugate
    • 34
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    This DCP1A antibody is un-conjugated
    Application
    • 42
    • 26
    • 8
    • 7
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody detects endogenous levels of SMIF protein. (region surrounding Ser133)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
    Purity
    > 95 % pure by SDS-PAGE
    Top Product
    Discover our top product DCP1A Primary Antibody
  • Application Notes
    ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    DO NOT FREEZE!
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    DCP1A (DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A))
    Alternative Name
    DCP1A (DCP1A Products)
    Synonyms
    DCP1A antibody, 1110066A22Rik antibody, 4930568L04Rik antibody, AU019772 antibody, D14Ertd817e antibody, Mitc1 antibody, SMIF antibody, RGD1561298 antibody, mitc1 antibody, HSA275986 antibody, Nbla00360 antibody, SMAD4IP1 antibody, smad4ip1 antibody, smif antibody, decapping mRNA 1A antibody, decapping mRNA 1A L homeolog antibody, DCP1A antibody, Dcp1a antibody, dcp1a antibody, dcp1a.L antibody
    Background
    Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-β-induced nuclear translocation of SMIF (1). The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.Synonyms: SMIF, Smad4-interacting transcriptional co-activator, Transcription factor SMIF, mRNA-decapping enzyme 1A
    Molecular Weight
    approx. 75 kDa
    Gene ID
    55802
    NCBI Accession
    NP_060873
    UniProt
    Q9NPI6
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