TWEAK antibody (N-Term)
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- Target See all TWEAK (TNFSF12) Antibodies
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Horse, Dog, Rabbit, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TWEAK antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LGLLLAVVSL GSRASLSAQE PAQEELVAEE DQDPSELNPQ TEESQDPAPF
- Predicted Reactivity
- Dog: 79%, Horse: 93%, Human: 100%, Mouse: 83%, Rabbit: 83%, Rat: 86%, Zebrafish: 82%
- Characteristics
- This is a rabbit polyclonal antibody against TNFSF12. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF12
- Top Product
- Discover our top product TNFSF12 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 249 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))
- Alternative Name
- TNFSF12 (TNFSF12 Products)
- Synonyms
- APO3L antibody, DR3LG antibody, TWEAK antibody, Apo3l antibody, Dr3l antibody, Dr3lg antibody, Tweak antibody, TNF superfamily member 12 antibody, tumor necrosis factor (ligand) superfamily, member 12 antibody, TNFSF12 antibody, Tnfsf12 antibody
- Background
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TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Protein Interaction Partner: DDIT3, TNFSF13B, LYN, OTUB1, TRAF2, BIRC2, AGGF1, TNFRSF12A, TNFRSF25,
Protein Size: 249 - Molecular Weight
- 17 kDa
- Gene ID
- 8742
- NCBI Accession
- NM_003809, NP_003800
- UniProt
- O43508
- Pathways
- Apoptosis
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