SNRNP200 antibody (N-Term)

Catalog No. ABIN2775221

Product Details anti-SNRNP200 Antibody

Target: SNRNP200 (Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Horse, Rabbit, Zebrafish (Danio rerio), Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNRNP200 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GDEDVYGEVR EEASDDDMEG DEAVVRCTLS ANLVASGELM SSKKKDLHPR

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against SNRNP200. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 2136 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SNRNP200

Target: SNRNP200 (Small Nuclear Ribonucleoprotein 200kDa (U5) (SNRNP200))

Alternative Name: SNRNP200 (SNRNP200 Products)

Synonyms: ASCC3L1 antibody, BRR2 antibody, HELIC2 antibody, RP33 antibody, U5-200KD antibody, small nuclear ribonucleoprotein U5 subunit 200 antibody, SNRNP200 antibody

Background: Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa.
Alias Symbols: ASCC3L1, BRR2, FLJ11521, HELIC2, RP33, U5-200KD
Protein Interaction Partner: PRPF8, EMD, CDKN1A, SUMO2, STAU1, UBC, SUMO1, LGR4, WWOX, RPA3, RPA2, RPA1, ERG, SUZ12, EZH2, EED, RNF2, rev, ELP3, KIAA1033, WDHD1, POLR2H, PIN1, USP34, TSC22D1, PARK2, FBXO6, TARDBP, PRPF4B, UBD, USP19, LSM8, SNRNP200, SF3B2, RBM5, ITGA4, FN1, RNF113A,
Protein Size: 2136

Molecular Weight: 244 kDa

Gene ID: 23020

NCBI Accession: NM_014014, NP_054733

UniProt: O75643

Pathways: Ribonucleoprotein Complex Subunit Organization