KCNN2 antibody (C-Term)
-
- Target See all KCNN2 Antibodies
- KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio), Saccharomyces cerevisiae
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This KCNN2 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL NDQANTLVDL AKTQNIMYDM
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 100%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against KCNN2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN2
- Top Product
- Discover our top product KCNN2 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 579 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
-
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 24, pp. 8341-53, (2012) (PubMed).
: "
-
Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 24, pp. 8341-53, (2012) (PubMed).
-
- Target
- KCNN2 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 2 (KCNN2))
- Alternative Name
- KCNN2 (KCNN2 Products)
- Synonyms
- KCNN2 antibody, SK2 antibody, KCa2.2 antibody, SKCA2 antibody, SKCa 2 antibody, hSK2 antibody, fri antibody, potassium calcium-activated channel subfamily N member 2 antibody, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 antibody, KCNN2 antibody, Kcnn2 antibody
- Background
-
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes.
Alias Symbols: SK2, hSK2, SKCA2, KCa2.2
Protein Interaction Partner: SRPK2, SRPK1, UBC, ACTN2, KCNN2, CALM1,
Protein Size: 579 - Molecular Weight
- 64 kDa
- Gene ID
- 3781
- NCBI Accession
- NM_021614, NP_067627
- UniProt
- Q9H2S1
-