MITF antibody (Middle Region)

Catalog No. ABIN2777228

Product Details anti-MITF Antibody

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Cow, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MITF antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NSNCEKEGFY KFEEQNRAES ECPGMNTHSR ASCMQMDDVI DDIISLESSY

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against MITF. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MITF

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MITF antibody (ABIN2777228)

Schartl, Wilde, Laisney, Taniguchi, Takeda, Meierjohann: "A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies." in: The Journal of investigative dermatology, Vol. 130, Issue 1, pp. 249-58, (2009) (PubMed).

Target Details for MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Alternative Name: MITF (MITF Products)

Synonyms: MITF antibody, ws2a antibody, mitfa antibody, MITF-A antibody, LOC100313655 antibody, mitfb antibody, CMM8 antibody, MI antibody, WS2 antibody, WS2A antibody, bHLHe32 antibody, BCC2 antibody, Bhlhe32 antibody, Gsfbcc2 antibody, Vitiligo antibody, Wh antibody, bw antibody, mi antibody, vit antibody, MITF-H antibody, MITF-M antibody, CMI9 antibody, melanogenesis associated transcription factor antibody, microphthalmia-associated transcription factor antibody, microphthalmia-associated transcription factor S homeolog antibody, Microphthalmia antibody, MITF antibody, mitf antibody, LOC100313655 antibody, mitf.S antibody, LOC100534525 antibody, MICROP antibody, Mitf antibody

Background: MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: CMM8, MI, WS2, WS2A, bHLHe32
Protein Interaction Partner: EBP, STUB1, HK3, EPAS1, LEF1, APP, HINT1, ELAVL1, CDK2, SUMO2, PSMD14, MARK3, PIAS3, PIAS2, PIAS1, SUMO1, UBE2I, PAX3, OTX2, PAX6, PATZ1, GSK3B, TFEC, EP300, RPS6KA1, TFEB, MAPK14, TFE3, MAPK1, SPI1, FOS, CTNNB1, CDKN1A, RB1,
Protein Size: 357

Molecular Weight: 39 kDa

Gene ID: 4286

NCBI Accession: NM_198178, NP_937821

Pathways: Chromatin Binding