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ISL1 antibody (C-Term)
ISL1
Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Rabbit, Cow, Dog, Guinea Pig, Sheep, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ISL1 Antibody
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Target
See all ISL1 Antibodies
ISL1
(ISL LIM Homeobox 1 (ISL1))
Binding Specificity
All epitopes for ISL1 antibodies
C-Term
Reactivity
All reactivities for ISL1 antibodies
Human, Mouse, Rat, Zebrafish (Danio rerio), Rabbit, Cow, Dog, Guinea Pig, Sheep, Horse
Host
All hosts for ISL1 antibodies
Rabbit
Clonality
All clonalities for ISL1 antibodies
Polyclonal
Conjugate
All conjugates for ISL1 antibodies
This ISL1 antibody is un-conjugated
Application
All applications for ISL1 antibodies
Western Blotting (WB)
Sequence
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP
Predicted Reactivity
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%
Characteristics
This is a rabbit polyclonal antibody against ISL1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human ISL1
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for ISL1
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Target
ISL1
(ISL LIM Homeobox 1 (ISL1))
Alternative Name
ISL1 (ISL1 Products )
Synonyms
Xisl-1 antibody, Xislet-1 antibody, islet1 antibody, ISLET-1 antibody, ISLET1 antibody, Isl-1 antibody, islet-1 antibody, isl-1=homeobox antibody, Islet-1 antibody, ISL LIM homeobox 1 S homeolog antibody, ISL LIM homeobox 1 antibody, ISL1 transcription factor, LIM/homeodomain antibody, isl1.S antibody, ISL1 antibody, Isl1 antibody, isl1 antibody
Background
ISL1 is a member of the LIM/homeodomain family of transcription factors. It binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. ISL1 is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Alias Symbols: ISLET1, Isl-1 Protein Interaction Partner: ZNF511, KDM1A, RELA, SMAD3, CDKN2B, CDK6, APP, COPS5, SSBP4, LHX4, LDB2, ISL2, PECR, LDB1, LHX1, LHX3, LMX1A, RLIM, LMO2, ESR1, NR2F1, ISL1, Protein Size: 349
Molecular Weight
39 kDa
Gene ID
3670
NCBI Accession
NM_002202 , NP_002193
UniProt
P61371
Pathways
Positive Regulation of Peptide Hormone Secretion , Intracellular Steroid Hormone Receptor Signaling Pathway , Peptide Hormone Metabolism , Regulation of Intracellular Steroid Hormone Receptor Signaling , Nuclear Hormone Receptor Binding , Chromatin Binding
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