ELF3 antibody (Middle Region)
-
- Target See all ELF3 Antibodies
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
-
Binding Specificity
- Middle Region
-
Reactivity
- Human, Cow, Dog, Rabbit, Horse, Pig
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This ELF3 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- GSCGAGAPSP GSSDVSTAGT GASRSSHSSD SGGSDVDLDP TDGKLFPSDG
- Predicted Reactivity
- Cow: 86%, Dog: 79%, Horse: 92%, Human: 100%, Pig: 93%, Rabbit: 100%
- Characteristics
- This is a rabbit polyclonal antibody against ELF3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human Elf3
- Top Product
- Discover our top product ELF3 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 371 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Alternative Name
- Elf3 (ELF3 Products)
- Synonyms
- ert antibody, esx antibody, epr-1 antibody, ese-1 antibody, ESE-1 antibody, ESX antibody, jen antibody, EPR-1 antibody, ERT antibody, E74 like ETS transcription factor 3 antibody, E74-like factor 3 antibody, elf3 antibody, Elf3 antibody, ELF3 antibody
- Background
-
ELF3 is a novel, highly tissue-restricted member of the ets transcription factor/oncogene family. ELF3 contains two putative DNA binding domains: an ETS domain, which is unique in that the 5' half shows relatively weak homology to known ets factors, and an A/T hook domain, found in HMG proteins and various other nuclear factors. In contrast to any known ets factors, ELF3 is expressed exclusively in epithelial cells. ELF3 is expected to be a critical regulator of epithelial cell differentiation. ETS factor ELF3 is a transcriptional regulator of angiopoietin-1 gene regulation in the setting of inflammation. ELF3 overexpressed early during human breast tumorigenesis. ELF3 expression confers a transformed and in vitro metastatic phenotype to otherwise normal MCF-12A cells. ELF3 mediates the expression of TGF-beta RII, and the transcriptional inhibition of ets-related transcription factor could be a one of the mechanisms of colonic carcinogenesis. ELF3 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
Alias Symbols: EPR-1, ERT, ESE-1, ESX
Protein Interaction Partner: MED23, XRCC5, RPL6, XRCC6, EP300, CBR3, Jun, MYC, BTRC, UBC, PAK1, TAF9, SUMO2, TBP, EPS15, CREBBP, NFKB1, EGFR, ERBB2, EHF, GANAB, ISG15, TARS, P4HB, KRT82, KRT31, JAK1, EEF1D, DDX3X, CALR, ATIC,
Protein Size: 371 - Molecular Weight
- 41 kDa
- Gene ID
- 1999
- NCBI Accession
- NM_004433, NP_004424
- UniProt
- P78545
-