PSMC3 antibody (Middle Region)
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- Target See all PSMC3 Antibodies
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Zebrafish (Danio rerio), Cow, Rabbit, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PSMC3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- TKRFDSEKAG DREVQRTMLE LLNQLDGFQP NTQVKVIAAT NRVDILD
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
- Characteristics
- This is a rabbit polyclonal antibody against PSMC3. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PSMC3
- Top Product
- Discover our top product PSMC3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 439 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." in: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor." in: International journal of cancer. Journal international du cancer, Vol. 111, Issue 3, pp. 338-47, (2004) (PubMed).
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- Target
- PSMC3 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 3 (PSMC3))
- Alternative Name
- PSMC3 (PSMC3 Products)
- Synonyms
- TBP1 antibody, TBP-1 antibody, wu:fb39a02 antibody, zgc:86713 antibody, psmc3 antibody, MGC89608 antibody, PSMC3 antibody, NV15940 antibody, 23.m06430 antibody, DDBDRAFT_0186002 antibody, DDBDRAFT_0232967 antibody, DDB_0186002 antibody, DDB_0232967 antibody, psmc3-b antibody, tbp10 antibody, psmc3-a antibody, proteasome 26S subunit, ATPase 3 antibody, proteasome (prosome, macropain) 26S subunit, ATPase 3 antibody, 26S protease regulatory subunit 6A antibody, 26S protease regulatory subunit 6a antibody, 26S protease regulatory subunit 6A-B antibody, 26S protease regulatory subunit 6A, putative antibody, proteasome 26S subunit, ATPase 3 S homeolog antibody, nth-like DNA glycosylase 1 S homeolog antibody, PSMC3 antibody, Psmc3 antibody, HCAG_00069 antibody, GL50803_4365 antibody, EDI_316920 antibody, CpipJ_CPIJ006888 antibody, CpipJ_CPIJ006889 antibody, CpipJ_CPIJ010864 antibody, prs6a antibody, psmc3 antibody, LOC100115023 antibody, BBOV_IV004580 antibody, CGB_M2140W antibody, psmC3 antibody, LOC100637883 antibody, psmc3.S antibody, nthl1.S antibody
- Background
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PSMC3 is a subunit of the 26S proteasome. 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9
Alias Symbols: TBP1
Protein Interaction Partner: AMOTL2, UBC, PSMD9, PSMC6, PSMC3, KDM1A, HUWE1, SUMO2, PSMD14, MDM2, ASB11, UCHL5, PSMD3, PSMD2, PSMD1, PSMC2, PSMC1, ADRM1, JKAMP, FBXO6, PARK2, BAG3, GADD45A, NOS2, MYC, PSMD13, PSMC4, PSMA8, UBFD1, ECD, STIP1, RANBP9, PSMD6, ZFYVE16, USP14, RUVBL1, PSM
Protein Size: 439 - Molecular Weight
- 45 kDa
- Gene ID
- 5702
- NCBI Accession
- NM_002804, NP_002795
- UniProt
- Q6IBS1
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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