Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibody

Details for Product No. ABIN2779047, Supplier: Log in to see
Antigen
  • mcts1
  • MCT-1
  • MGC89874
  • MCTS1
  • MCT1
  • 1500019M23Rik
  • zgc:56242
  • MCT-1A
  • mct-1
  • mct1
  • HHF7
  • MCT
  • RATMCT1
  • RNMCT1
  • AL022710
  • Mct1
  • MCT1a
  • cb517
  • zgc:55682
  • modifier of curly tail 1
  • malignant T cell amplified sequence 1
  • monocarboxylate transporter 1
  • solute carrier family 16 (monocarboxylate transporter), member 1
  • solute carrier family 16 (monocarboxylic acid transporters), member 1
  • solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
  • mct1
  • TEgg094c21.2
  • MCTS1
  • mcts1
  • Mcts1
  • mcts1-a
  • MCT1
  • SLC16A1
  • Slc16a1
  • slc16a1
Epitope
N-Term
16
10
7
7
4
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
79
34
23
5
5
5
4
4
3
2
2
1
1
1
1
Host
Rabbit
54
18
12
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
61
25
14
13
12
7
2
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MCTS1
Blocking Peptide Blocking peptide for this product available: ABIN979917
Sequence MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against MCTS1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MCTS1 (MCTS1 Antibody Abstract)
Background MCTS1 is an anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer, and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.
Alias Symbols: MCT-1, MCT1
Protein Interaction Partner: ASB6, IPO9, OGFOD1, STK26, UBXN1, ISOC1, TWF2, PROSC, TUBB4B, PDCD6IP, NAE1, USP5, YWHAE, UBA1, PTMA, TWF1, MYO1E, IPO5, HMGB3, HDGF, DHX15, ATIC, UBC, DENR, SUMO1,
Protein Size: 181
Molecular Weight 20 kDa
Gene ID 28985
NCBI Accession NM_014060, NP_054779
UniProt Q9ULC4
Research Area Transporters
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 181 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibody (ABIN2779047) WB Suggested Anti-MCTS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Shi, Levenson, Gartenhaus: "Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter." in: Journal of cellular biochemistry, Vol. 90, Issue 1, pp. 68-79, 2003 (PubMed).