AIRE antibody (N-Term)
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- Target See all AIRE Antibodies
- AIRE (Autoimmune Regulator (AIRE))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rat, Dog, Horse, Cow, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AIRE antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP
- Predicted Reactivity
- Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%
- Characteristics
- This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
- Top Product
- Discover our top product AIRE Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 545 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).
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AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." in: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, (2005) (PubMed).
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- Target
- AIRE (Autoimmune Regulator (AIRE))
- Alternative Name
- AIRE (AIRE Products)
- Synonyms
- AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
- Background
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AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
Protein Size: 545 - Molecular Weight
- 58 kDa
- Gene ID
- 326
- NCBI Accession
- NM_000383, NP_000374
- UniProt
- O43918
- Pathways
- Chromatin Binding
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