AHRR antibody (Middle Region)

Catalog No. ABIN2779915

Product Details anti-AHRR Antibody

Target: AHRR (Aryl-Hydrocarbon Receptor Repressor (AHRR))

Binding Specificity: Middle Region

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AHRR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CLRGGPDLLD PKGTSGDREE EDQKHILRRS PGAWGQREMH KYSYGLETPV

Predicted Reactivity: Mouse: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against Ahrr. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 701 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AHRR

Target: AHRR (Aryl-Hydrocarbon Receptor Repressor (AHRR))

Alternative Name: Ahrr (AHRR Products)

Synonyms: mKIAA1234 antibody, AHH antibody, AHHR antibody, bHLHe77 antibody, ahh antibody, ahhr antibody, bhlhe77 antibody, ahrr2 antibody, aryl-hydrocarbon receptor repressor antibody, aryl hydrocarbon receptor repressor-like antibody, uncharacterized LOC723045 antibody, aryl-hydrocarbon receptor repressor L homeolog antibody, aryl hydrocarbon receptor repressor antibody, aryl-hydrocarbon receptor repressor b antibody, Ahrr antibody, AHRR antibody, LOC529500 antibody, LOC723045 antibody, ahrr.L antibody, LOC100455869 antibody, ahrr antibody, LOC100136487 antibody, ahrrb antibody

Background: Ahrr mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Ahrr represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Ahrr represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Alias Symbols: KIAA1234, mKIAA1234
Protein Size: 701

Molecular Weight: 78 kDa

Gene ID: 11624

NCBI Accession: NM_009644, NP_033774

UniProt: Q3U1U7

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha