NR1H3 antibody (C-Term)

Catalog No. ABIN2780709

Product Details anti-NR1H3 Antibody

Target: NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Horse, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR1H3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IHHPHDRLMF PRMLMKLVSL RTLSSVHSEQ VFALRLQDKK LPPLLSEIWD

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against NR1H3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NR1H3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 447 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NR1H3 antibody (ABIN2780709)

Torra, Ismaili, Feig, Xu, Cavasotto, Pancratov, Rogatsky, Neubert, Fisher, Garabedian: "Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2626-36, (2008) (PubMed).

Target Details for NR1H3

Target: NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))

Alternative Name: NR1H3 (NR1H3 Products)

Synonyms: NR1H3 antibody, LXR-a antibody, LXRA antibody, RLD-1 antibody, AU018371 antibody, LXR antibody, RLD1 antibody, Unr1 antibody, LXRalpha antibody, LXR-alpha antibody, im:7141239 antibody, wu:fd59b01 antibody, zgc:113339 antibody, zgc:158542 antibody, nuclear receptor subfamily 1 group H member 3 antibody, nuclear receptor subfamily 1, group H, member 3 antibody, NR1H3 antibody, nr1h3 antibody, Nr1h3 antibody

Background: Interaction of NR1H3 with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. NR1H3 are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. NR1H3 Plays an important role in the regulation of cholesterol homeostasis.
Alias Symbols: LXR-a, LXRA, RLD-1
Protein Interaction Partner: RXRG, RXRB, MDFI, SUV39H1, KDM1A, BARD1, MSTO1, HSP90AA1, PIAS1, APP, NR3C1, MYC, ZXDC, TMEM161A, ING3, NCOA6, NCOR1, KAT2B, EIF3I, NRIP1, NCOA3, SRC, RXRA, FOXO3, ACTN1, SS18L1, LZTR1, EDF1, RARA, NR0B2, SYT1, PPARA, SIRT1, UBC, CEP350,
Protein Size: 447

Molecular Weight: 50 kDa

Gene ID: 10062

NCBI Accession: NM_005693, NP_005684

UniProt: Q13133

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C