Derlin-3 antibody (C-Term)

Catalog No. ABIN2781869

Product Details anti-Derlin-3 Antibody

Target: Derlin-3 (DERL3) (Der1-Like Domain Family, Member 3 (DERL3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Derlin-3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: YYFLEDVFPN QPGGKRLLQT PGFLKLLLDA PAEDPNYLPL PEEQPGPHLP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against DERL3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DERL3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 235 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Derlin-3

Target: Derlin-3 (DERL3) (Der1-Like Domain Family, Member 3 (DERL3))

Alternative Name: DERL3 (DERL3 Products)

Synonyms: 1810006I20Rik antibody, 1810063P04Rik antibody, IZP6 antibody, derlin-3 antibody, zgc:63991 antibody, C22orf14 antibody, LLN2 antibody, derlin 3 antibody, Der1-like domain family, member 3 antibody, DERL3 antibody, Derl3 antibody, derl3 antibody

Background: DERL3 belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL3 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM].
Alias Symbols: C22orf14, IZP6, MGC71803, LLN2, derlin-3
Protein Interaction Partner: ERN1, UBE2J1, SERPINA1, MFI2, AMFR,
Protein Size: 235

Molecular Weight: 27 kDa

Gene ID: 91319

NCBI Accession: NM_001002862, NP_001002862

UniProt: Q96Q80

Pathways: ER-Nucleus Signaling