PI3 antibody (Middle Region)
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- Target See all PI3 Antibodies
- PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Cow, Pig, Sheep
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PI3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- KGRVPFNGQD PVKGQVSVKG QDKVKAQEPV KGPVSTKPGS CPIILIRCAM
- Predicted Reactivity
- Cow: 85%, Human: 100%, Pig: 77%, Sheep: 77%
- Characteristics
- This is a rabbit polyclonal antibody against PI3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PI3
- Top Product
- Discover our top product PI3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 117 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))
- Alternative Name
- PI3 (PI3 Products)
- Synonyms
- ESI antibody, SKALP antibody, WAP3 antibody, WFDC14 antibody, cementoin antibody, trappin-2 antibody, TRAPPIN-2 antibody, elafin antibody, peptidase inhibitor 3 antibody, peptidase inhibitor 3, skin-derived (SKALP) antibody, PI3 antibody
- Background
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PI3 is an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. PI3 contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. PI3 belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ESI, MGC13613, SKALP, WAP3, WFDC14, cementoin
Protein Interaction Partner: EVPL, CELA1, LOR, KRT1, CSTA,
Protein Size: 117 - Molecular Weight
- 6 kDa
- Gene ID
- 5266
- NCBI Accession
- NM_002638, NP_002629
- UniProt
- P19957
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