PSMB9 antibody (C-Term)
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- Target See all PSMB9 Antibodies
- PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Pig, Rabbit, Cow, Horse, Guinea Pig, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PSMB9 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- RRFTTDAIAL AMSRDGSSGG VIYLVTITAA GVDHRVILGN ELPKFYDE
- Predicted Reactivity
- Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against PSMB9. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human PSMB9
- Top Product
- Discover our top product PSMB9 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 219 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))
- Alternative Name
- PSMB9 (PSMB9 Products)
- Synonyms
- LMP2 antibody, ring12 antibody, MHC-linked antibody, psmb9b antibody, lmp2 antibody, lmp2b antibody, psmb9 antibody, Lmp-2 antibody, Lmp2 antibody, PSMB6i antibody, RING12 antibody, beta1i antibody, psmb9-A antibody, macropain antibody, prosome antibody, wu:fa66f04 antibody, wu:fj22d05 antibody, zgc:91842 antibody, psmb9a antibody, proteasome subunit beta 9 antibody, LMP2 antibody, proteasome subunit beta type-9b antibody, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) antibody, proteasome subunit beta 9 S homeolog antibody, proteasome subunit beta 9a antibody, proteasome (prosome, macropain) subunit, beta type, 9a antibody, psmb9 antibody, PSMB9 antibody, psmb9-b antibody, Psmb9 antibody, psmb9.S antibody, psmb9a antibody
- Background
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The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. PSMB9 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This subunit is involved in antigen processing to generate class I binding peptides. Expression of PSMB9 is induced by gamma interferon and it replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified, both isoforms are processed to yield the same mature subunit.
Alias Symbols: LMP2, MGC70470, RING12, PSMB6i, beta1i
Protein Interaction Partner: NCOA3, TCEB3, SRC, POLR2L, POLR2K, POLR2J, POLR2I, POLR2H, POLR2G, POLR2F, POLR2E, POLR2D, POLR2C, POLR2B, ESR1, NCOA2, UBC, HCVgp1, PSMA2, PSMB5, PSME2, PSME1, PSMB6, PSMA3, POMP, PSMB8, PSMB7, PSMA7, PSMA1, PSMB9, PSMC5, PSMA4, POLR2A, NCOA1, PSMB10,
Protein Size: 219 - Molecular Weight
- 21 kDa
- Gene ID
- 5698
- NCBI Accession
- NM_002800, NP_002791
- UniProt
- P28065
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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