PILRA antibody (N-Term)
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- Target See all PILRA Antibodies
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
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Binding Specificity
- N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PILRA antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- IPFSFYYPWE LATAPDVRIS WRRGHFHRQS FYSTRPPSIH KDYVNRLFLN
- Specificity
- 100 % homologous to all four isoforms of human PILRA.
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against PILRA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human PILRA
- Top Product
- Discover our top product PILRA Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 175 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PILRA (Paired Immunoglobin-Like Type 2 Receptor alpha (PILRA))
- Alternative Name
- PILRA (PILRA Products)
- Synonyms
- PILRA antibody, FDF03 antibody, AV021745 antibody, RGD1562847 antibody, paired immunoglobin like type 2 receptor alpha antibody, paired immunoglobulin-like type 2 receptor alpha antibody, paired immunoglobin-like type 2 receptor alpha antibody, PILRA antibody, LOC489841 antibody, Pilra antibody
- Background
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Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Alias Symbols: FDF03
Protein Interaction Partner: DNPH1, SORBS1, PTPN6, PTPN11, FCAR,
Protein Size: 175 - Molecular Weight
- 18 kDa
- Gene ID
- 29992
- NCBI Accession
- NM_178273, NP_840057
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