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MAVS antibody (N-Term)

MAVS Reactivity: Human, Mouse, Cow WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2783802
  • Target See all MAVS Antibodies
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Binding Specificity
    • 15
    • 13
    • 8
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 48
    • 37
    • 4
    • 1
    • 1
    Human, Mouse, Cow
    Host
    • 69
    • 7
    Rabbit
    Clonality
    • 71
    • 5
    Polyclonal
    Conjugate
    • 34
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAVS antibody is un-conjugated
    Application
    • 68
    • 37
    • 13
    • 13
    • 11
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    ETQAPESPGE NSEQALQTLS PRAIPRNPDG GPLESSSDLA ALSPLTSSGH
    Predicted Reactivity
    Cow: 79%, Human: 100%, Mouse: 79%
    Characteristics
    This is a rabbit polyclonal antibody against VISA. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human VISA
    Top Product
    Discover our top product MAVS Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 896 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Alternative Name
    VISA (MAVS Products)
    Synonyms
    CARDIF antibody, IPS-1 antibody, IPS1 antibody, VISA antibody, D430028G21Rik antibody, Visa antibody, cardif antibody, wu:fj20d04 antibody, zgc:158392 antibody, mitochondrial antiviral signaling protein antibody, MAVS antibody, Mavs antibody, mavs antibody
    Background
    Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3, MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK, MIM 600664) and IKKB (IKBKB, MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE, MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1, MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1, MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: CARDIF, DKFZp666M015, FLJ27482, FLJ41962, IPS-1, KIAA1271, MAVS, IPS1, VISA
    Protein Interaction Partner: MIB2, KCNIP3, DDX58, UBC, TRAF6, TRAF3, UBXN1, TMEM173, SMURF2, HCVgp1, AMFR, MFN1, MFN2, MUL1, TOMM70A, FLOT2, NDFIP1, SMURF1, TBK1, IKBKG, TICAM1, TRAF2, MAP3K7, SRC, IRF7, IRF3, IKBKE, TSPAN6, RARRES3, ECSIT, PCBP2, ITCH, IFIH1, PSMA7, WDR5, HECTD3, PD
    Protein Size: 896
    Molecular Weight
    56 kDa
    Gene ID
    57506
    NCBI Accession
    NM_020746, NP_065797
    UniProt
    Q2HWT5
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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