ABAT antibody (Middle Region)
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- Target See all ABAT Antibodies
- ABAT (4-Aminobutyrate Aminotransferase (ABAT))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Rabbit, Goat, Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ABAT antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- YRSKERGQRG FSQEELETCM INQAPGCPDY SILSFMGAFH GRTMGCLATT
- Predicted Reactivity
- Cow: 93%, Dog: 86%, Goat: 77%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against ABAT. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ABAT
- Top Product
- Discover our top product ABAT Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 500 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ABAT (4-Aminobutyrate Aminotransferase (ABAT))
- Alternative Name
- ABAT (ABAT Products)
- Synonyms
- cb880 antibody, fj82a01 antibody, wu:fj82a01 antibody, BA0325 antibody, PSPTO0259 antibody, PSPTO0301 antibody, PSPTO1890 antibody, GABA-AT antibody, GABAT antibody, NPD009 antibody, GABA-T antibody, L-AIBAT antibody, 9630038C02Rik antibody, AI255750 antibody, ENSMUSG00000051226 antibody, Gabaat antibody, Gabat antibody, Gm9851 antibody, I54 antibody, Laibat antibody, X61497 antibody, beta-AlaAT antibody, 4-aminobutyrate aminotransferase antibody, 4-aminobutyrate--2-oxoglutarate transaminase antibody, GABA aminotransferase PLP-dependent PuuE antibody, 4-aminobutyrate aminotransferase, mitochondrial antibody, aspartate aminotransferase family protein antibody, 4-aminobutyrate aminotransferase S homeolog antibody, ABAT antibody, abat antibody, gabT antibody, puuE antibody, gabT-1 antibody, gabT-2 antibody, gabT-3 antibody, CNE01830 antibody, Mmwyl1_0047 antibody, CpipJ_CPIJ008729 antibody, KCR_RS04555 antibody, Bcenmc03_4909 antibody, Hden_0972 antibody, Dbac_2000 antibody, Mesil_2400 antibody, Trad_0121 antibody, abat.S antibody, Abat antibody
- Background
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4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Alias Symbols: GABA-AT, GABAT, NPD009
Protein Interaction Partner: LGR4, BAG3, ALDH5A1, ABAT,
Protein Size: 500 - Molecular Weight
- 56 kDa
- Gene ID
- 18
- NCBI Accession
- NM_020686, NP_065737
- UniProt
- P80404
- Pathways
- Monocarboxylic Acid Catabolic Process
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