FTL antibody (Middle Region)

Catalog No. ABIN2785638

Product Details anti-FTL Antibody

Target: FTL (Ferritin, Light Polypeptide (FTL))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Cow, Dog, Pig, Rabbit, Guinea Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FTL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: ALLDLHALGS ARTDPHLCDF LETHFLDEEV KLIKKMGDHL TNLHRLGGPE

Predicted Reactivity: Cow: 79%, Dog: 93%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%, Sheep: 77%

Characteristics: This is a rabbit polyclonal antibody against FTL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FTL

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 175 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FTL

Target: FTL (Ferritin, Light Polypeptide (FTL))

Alternative Name: FTL (FTL Products)

Synonyms: NBIA3 antibody, apoferritin antibody, ferritin antibody, fhc antibody, fth antibody, fth1 antibody, fthl6 antibody, ftn-2 antibody, pig15 antibody, plif antibody, FT antibody, Ftl antibody, Ftl-1 antibody, L-ferritin antibody, FTL antibody, Ftl1 antibody, FTL2 antibody, FTD antibody, ferritin light chain antibody, ferritin, heavy polypeptide 1 L homeolog antibody, ferritin light polypeptide 1 antibody, ferritin, light polypeptide antibody, ferritin light-chain antibody, ferritin light chain 1 antibody, FTL antibody, fth1.L antibody, Ftl1 antibody, CpipJ_CPIJ004069 antibody, Ftl antibody

Background: FTL is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC71996, NBIA3
Protein Interaction Partner: USHBP1, SDCBP, MYOG, KPNA3, FTL, FTH1, CEP250, CEP57, AURKA, PACSIN2, COL4A3BP, IGSF8, NAMPT, SMAD9, HTT, VKORC1, PPP1CC, POLR2D, HSPD1, HSP90AB3P, EIF4G1, TOX4, MYOC, UBC, CLEC4G, RAP2A, PIK3CA, GRB2, UCHL5, MPHOSPH6, TAF10, MPP6, IGDCC3, MAP3K12, KNG1,
Protein Size: 175

Molecular Weight: 20 kDa

Gene ID: 2512

NCBI Accession: NM_000146, NP_000137

UniProt: P02792

Pathways: Transition Metal Ion Homeostasis