DAAM1 antibody (Middle Region)

Catalog No. ABIN2786070

Product Details anti-DAAM1 Antibody

Target: DAAM1 (Dishevelled Associated Activator of Morphogenesis 1 (DAAM1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DAAM1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GNTVQYWLLL DRIIQQIVIQ NDKGQDPDST PLENFNIKNV VRMLVNENEV

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against DAAM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DAAM1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1078 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DAAM1

Target: DAAM1 (Dishevelled Associated Activator of Morphogenesis 1 (DAAM1))

Alternative Name: DAAM1 (DAAM1 Products)

Synonyms: 1700066F09Rik antibody, 2310028E21Rik antibody, AI503486 antibody, E130308H01 antibody, mKIAA0666 antibody, daam-1 antibody, xdaam1 antibody, daam1 antibody, DAAM1 antibody, DKFZp468D0524 antibody, daam1l antibody, fc83b10 antibody, si:ch211-87i20.1 antibody, wu:fc83b10 antibody, dishevelled associated activator of morphogenesis 1 antibody, dishevelled associated activator of morphogenesis 1 S homeolog antibody, dishevelled associated activator of morphogenesis 1a antibody, dishevelled associated activator of morphogenesis 1b antibody, DAAM1 antibody, Daam1 antibody, daam1.S antibody, daam1a antibody, daam1 antibody, daam1b antibody

Background: Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.
Alias Symbols: FLJ41657, KIAA0666
Protein Interaction Partner: UBC, PRPF40A, B3GALT4, AMBP, MAP3K7, DVL2, DVL1, RHOA,
Protein Size: 1078

Molecular Weight: 123 kDa

Gene ID: 23002

NCBI Accession: NM_014992, NP_055807

UniProt: Q9Y4D1

Pathways: WNT Signaling