Selectin E/CD62e antibody (N-Term)

Catalog No. ABIN2787940

Product Details anti-Selectin E/CD62e Antibody

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Sheep, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Selectin E/CD62e antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK DVGMWNDERC

Predicted Reactivity: Cow: 92%, Dog: 86%, Guinea Pig: 86%, Horse: 79%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Sheep: 86%

Characteristics: This is a rabbit polyclonal antibody against SELE. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SELE

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 610 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Selectin E/CD62e

Target: Selectin E/CD62e (SELE) (Selectin E (SELE))

Alternative Name: SELE (SELE Products)

Synonyms: SELE antibody, CD62E antibody, ELAM antibody, ELAM1 antibody, ESEL antibody, LECAM2 antibody, E-selectin antibody, Elam antibody, selectin E antibody, selectin, endothelial cell antibody, SELE antibody, Sele antibody

Background: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Alias Symbols: CD62E, ELAM, ELAM1, ESEL, LECAM2
Protein Interaction Partner: LGALS3BP, SELL, SERPING1, PXN, PTK2, GLG1, SELPLG, FLNA, VCL, PTPN11, PLCG1, CD44, ACTN2, TLN1,
Protein Size: 610

Molecular Weight: 64 kDa

Gene ID: 6401

NCBI Accession: NM_000450, NP_000441

UniProt: P16581

Pathways: Thromboxane A2 Receptor Signaling