TIMP2 antibody (N-Term)
-
- Target See all TIMP2 Antibodies
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
-
Binding Specificity
- N-Term
-
Reactivity
- Human, Rat, Mouse, Cow, Zebrafish (Danio rerio), Rabbit, Guinea Pig, Dog, Horse, Sheep
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TIMP2 antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- NADVVIRAKA VSEKEVDSGN DIYGNPIKRI QYEIKQIKMF KGPEKDIEFI
- Predicted Reactivity
- Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%, Zebrafish: 79%
- Characteristics
- This is a rabbit polyclonal antibody against TIMP2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TIMP2
- Top Product
- Discover our top product TIMP2 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 220 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
- Alternative Name
- TIMP2 (TIMP2 Products)
- Synonyms
- CSC-21K antibody, DDC8 antibody, timp2l antibody, zgc:65967 antibody, zgc:85799 antibody, D11Bwg1104e antibody, Timp-2 antibody, TIMP-2 antibody, etID32613.12 antibody, fa96h09 antibody, timp2 antibody, wu:fa96h09 antibody, zgc:136726 antibody, TIMP metallopeptidase inhibitor 2 antibody, TIMP metallopeptidase inhibitor 2b antibody, tissue inhibitor of metalloproteinase 2 antibody, TIMP metallopeptidase inhibitor 2a antibody, TIMP metallopeptidase inhibitor 2 L homeolog antibody, TIMP2 antibody, timp2b antibody, Timp2 antibody, timp2a antibody, timp2.L antibody
- Background
-
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Alias Symbols: CSC-21K, Metalloproteinase inhibitor 2, TIMP2, TIMP metallopeptidase inhibitor 2, Tissue inhibitor of metalloproteinases 2, Timp2
Protein Interaction Partner: BAG3, ITGA3, MMP14, ITGB1, MMP2, MMP8, SNCG, PSMA7,
Protein Size: 220 - Molecular Weight
- 22 kDa
- Gene ID
- 7077
- NCBI Accession
- NM_003255, NP_003246
- UniProt
- P16035
- Pathways
- cAMP Metabolic Process
-