MRGPRX2 antibody (Middle Region)
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- Target See all MRGPRX2 Antibodies
- MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))
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Binding Specificity
- Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MRGPRX2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- VCVLLWALSL LLSILEGKFC GFLFSDGDSG WCQTFDFITA AWLIFLFMVL
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MRGPRX2. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human MRGPRX2
- Top Product
- Discover our top product MRGPRX2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 330 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))
- Alternative Name
- MRGPRX2 (MRGPRX2 Products)
- Synonyms
- MRGX2 antibody, G370024M05Rik antibody, MrgB10 antibody, Mrgprb10 antibody, MrgB1 antibody, Mrgprb1 antibody, MAS related GPR family member X2 antibody, MAS-related GPR, member X2 antibody, MRGPRX2 antibody, Mrgprx2 antibody
- Background
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MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Alias Symbols: MRGX2
Protein Interaction Partner: CORT,
Protein Size: 330 - Molecular Weight
- 37 kDa
- Gene ID
- 117194
- NCBI Accession
- NM_054030, NP_473371
- UniProt
- Q96LB1
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