MRGPRX1 antibody (C-Term)

Catalog No. ABIN2788263

Product Details anti-MRGPRX1 Antibody

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FLSALNSSAN PIIYFFVGSF RQRQNRQNLK LVLQRALQDA SEVDEGGGQL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against MRGPRX1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MRGPRX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 322 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MRGPRX1

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Alternative Name: MRGPRX1 (MRGPRX1 Products)

Synonyms: GPCR antibody, MRGX1 antibody, SNSR4 antibody, MrgC11 antibody, Mrgprc11 antibody, Snsr1 antibody, MAS related GPR family member X1 antibody, MAS-related GPR, member X1 antibody, MRGPRX1 antibody, Mrgprx1 antibody

Background: MRGPRX1 is an orphan receptor. MRGPRX1 is probably involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain. MRGPRX1 is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. MRGPRX1 is activated by the antimalarial drug, chloroquine and may mediate chloroquine-induced itch, in an histamine-independent manner.
Alias Symbols: GPCR, MRGX1, SNSR4
Protein Interaction Partner: GNG2, GNB1, GNAQ, GNAI2,
Protein Size: 322

Molecular Weight: 36 kDa

Gene ID: 259249

NCBI Accession: NM_147199, NP_671732

UniProt: Q96LB2