CYP3A5 antibody (N-Term)

Catalog No. ABIN2788347

Product Details anti-CYP3A5 Antibody

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Cow, Pig, Sheep, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP3A5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AITDPDVIRT VLVKECYSVF TNRRSLGPVG FMKSAISLAE DEEWKRIRSL

Predicted Reactivity: Cow: 79%, Dog: 91%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Mouse: 82%, Pig: 93%, Rat: 79%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against CYP3A5. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CYP3A5

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 502 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP3A5

Target: CYP3A5 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))

Alternative Name: CYP3A5 (CYP3A5 Products)

Synonyms: CP35 antibody, CYPIIIA5 antibody, P450PCN3 antibody, PCN3 antibody, cytochrome P450 family 3 subfamily A member 5 antibody, CYP3A5 antibody

Background: This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.
Alias Symbols: CP35, P450PCN3, PCN3, CYPIIIA5
Protein Interaction Partner: RDH13, ATOH8, ETV5,
Protein Size: 502

Molecular Weight: 57 kDa

Gene ID: 1577

NCBI Accession: NM_000777, NP_000768

UniProt: P51589

Pathways: Steroid Hormone Biosynthesis