MME antibody (Membrane Metallo-Endopeptidase) (C-Term)

Details for Product anti-MME Antibody No. ABIN2789467, Supplier: Log in to see
Antigen
  • CALLA
  • CD10
  • NEP
  • SFE
  • 6030454K05Rik
  • C85356
  • Nep
  • neprilysin
  • membrane metalloendopeptidase
  • membrane metallo endopeptidase
  • membrane metallo-endopeptidase
  • MME
  • Mme
Alternatives
anti-Human MME antibody for Immunoprecipitation
Epitope
C-Term
36
36
23
16
15
14
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12
10
8
8
6
6
5
5
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
623
98
82
16
14
3
3
2
1
1
1
1
1
1
1
Host
Rabbit
439
197
4
3
Clonality
Polyclonal
Conjugate
This MME antibody is un-conjugated
61
48
43
28
11
10
10
10
9
8
6
6
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6
5
5
5
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
316
308
214
180
129
85
83
50
49
21
13
10
5
4
4
2
2
2
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Blocking Peptide Blocking peptide for this product available: ABIN980144
Sequence EYAVNSIKTD VHSPGNFRII GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against MME. It was validated on Western Blot.
Purification Affinity Purified
Alternative Name MME (MME Antibody Abstract)
Background This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.
Alias Symbols: CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP, SFE
Protein Interaction Partner: MME, NPPA, AGT, HDAC8, UBC, NDRG1, FAM83F, RGPD6, POTEI, TUBB8, UBAC2, KBTBD3, MTDH, ITFG3, ARMC10, FAHD1, CDK5RAP3, MRPL44, NUCKS1, MRPS25, LAMTOR1, DNAJB12, SDF4, METTL7A, NNT, CPSF6, PDIA5, RUVBL2, TM9SF1, MRVI1, CLEC4M, ZMPSTE24, RBM39, ATP5J2, SLC9A3
Protein Size: 750
Molecular Weight 83 kDa
Gene ID 4311
NCBI Accession NM_007287, NP_009218
UniProt P08473
Pathways RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 750 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Membrane Metallo-Endopeptidase (MME) (C-Term) antibody (ABIN2789467) anti-Membrane Metallo-Endopeptidase (MME) (C-Term) antibody
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