ASCL1 antibody (Middle Region)
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- Target See all ASCL1 Antibodies
- ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Guinea Pig, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ASCL1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- AGVLSPTISP NYSNDLNSMA GSPVSSYSSD EGSYDPLSPE EQELLDFTNW
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against ASCL1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ASCL1
- Top Product
- Discover our top product ASCL1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 236 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
- Alternative Name
- ASCL1 (ASCL1 Products)
- Synonyms
- ASH1 antibody, HASH1 antibody, MASH1 antibody, bHLHa46 antibody, AI225900 antibody, Mash1 antibody, ASCL1 antibody, Zash-1a antibody, ash antibody, asha antibody, id:ibd5085 antibody, im:7138587 antibody, si:dkey-264k15.2 antibody, zash1a antibody, zasha antibody, Xash1 antibody, ascl1-A antibody, Zash-1b antibody, ashb antibody, zashb antibody, achaete-scute family bHLH transcription factor 1 antibody, achaete-scute family bHLH transcription factor 1a antibody, achaete-scute family bHLH transcription factor 1 L homeolog antibody, achaete-scute complex homolog 1 antibody, achaete-scute family bHLH transcription factor 1b antibody, ASCL1 antibody, Ascl1 antibody, ascl1a antibody, ascl1.L antibody, LOC100220505 antibody, ascl1b antibody
- Background
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ASCL1 may play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. ASCL1 is essential for the generation of olfactory and autonomic neurons. ASCL1 activates transcription by binding to the E box (5'-CANNTG-3').This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ASH1, HASH1, MASH1, bHLHa46
Protein Interaction Partner: MEF2D, MEF2C, MEF2A, NEUROG2, UBQLN1, EP300, TCF4, BMP2, ASCL1,
Protein Size: 236 - Molecular Weight
- 25 kDa
- Gene ID
- 429
- NCBI Accession
- NM_004316, NP_004307
- UniProt
- P50553
- Pathways
- Dopaminergic Neurogenesis
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