DR3/LARD antibody (Middle Region)
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- Target See all DR3/LARD (TNFRSF25) Antibodies
- DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Guinea Pig, Rabbit, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DR3/LARD antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- GRFRDQQYEM LKRWRQQQPA GLGAVYAALE RMGLDGCVED LRSRLQRGP
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against TNFRSF25. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human TNFRSF25
- Top Product
- Discover our top product TNFRSF25 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 372 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
- Alternative Name
- TNFRSF25 (TNFRSF25 Products)
- Synonyms
- APO-3 antibody, DDR3 antibody, DR3 antibody, LARD antibody, TNFRSF12 antibody, TR3 antibody, TRAMP antibody, WSL-1 antibody, WSL-LR antibody, Tnfrsf12 antibody, Wsl antibody, TNFRSF25 antibody, TNF receptor superfamily member 25 antibody, tumor necrosis factor receptor superfamily, member 25 antibody, TNFRSF25 antibody, Tnfrsf25 antibody
- Background
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TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
Alias Symbols: APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
Protein Interaction Partner: RIPK1, TRADD, UBC, TRAF2, MAPK1, TNFSF15, BAG4, TNFSF12, TNFRSF1A, TNFRSF25, NOL3, DAP3,
Protein Size: 372 - Molecular Weight
- 38 kDa
- Gene ID
- 8718
- NCBI Accession
- NM_148967, NP_683868
- UniProt
- Q93038
- Pathways
- Apoptosis
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