Chemokine (C-C Motif) Ligand 8 (CCL8) (Middle Region) antibody

Details for Product No. ABIN2792194, Supplier: Log in to see
Antigen
  • HC14
  • MCP-2
  • MCP2
  • SCYA10
  • SCYA8
  • 1810063B20Rik
  • AB023418
  • Mcp2
  • Scya8
  • chemokine (C-C motif) ligand 8
  • monocyte chemoattractant protein-2 precursor
  • CCL8
  • Ccl8
  • MCP-2
Epitope
Middle Region
15
6
6
5
2
1
1
1
Reactivity
Human
91
51
3
2
1
Host
Rabbit
72
39
15
1
Clonality
Polyclonal
Conjugate
Un-conjugated
15
7
6
4
4
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
101
57
15
14
8
7
4
4
4
3
2
1
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human CCL8
Sequence SYTRITNIQC PKEAVIFKTK RGKEVCADPK ERWVRDSMKH LDQIFQNLKP
Predicted Reactivity Human: 100%
Characteristics This is a rabbit polyclonal antibody against CCL8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CCL8 (CCL8 Antibody Abstract)
Background CCL8 gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HC14, MCP-2, MCP2, SCYA10, SCYA8
Protein Interaction Partner: ACKR2, ACKR4, CCR5, CCR3, CCR2, CCR1, MMP3, VCAN, ACKR1,
Protein Size: 99
Molecular Weight 9 kDa
Gene ID 6355
NCBI Accession NM_005623, NP_005614
UniProt P80075
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 99 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Chemokine (C-C Motif) Ligand 8 (CCL8) (Middle Region) antibody (ABIN2792194) anti-Chemokine (C-C Motif) Ligand 8 (CCL8) (Middle Region) antibody
Background publications Hori, Naishiro, Sohma, Suzuki, Hatakeyama, Yamamoto, Sonoda, Mizue, Imai, Tsutsumi, Kokai: "CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease." in: Blood, Vol. 111, Issue 8, pp. 4403-12, 2008 (PubMed).