CD137 antibody (Tumor Necrosis Factor Receptor Superfamily, Member 9)

Details for Product anti-TNFRSF9 Antibody No. ABIN2800694, Supplier: Log in to see
Antigen
  • TNFRSF9
  • zgc:136557
  • 4-1BB
  • CD137
  • CDw137
  • ILA
  • A930040I11Rik
  • AA408498
  • AI325004
  • Cd137
  • Ly63
  • tumor necrosis factor receptor superfamily member 9
  • TNF receptor superfamily member 9
  • tumor necrosis factor receptor superfamily, member 9a
  • tumor necrosis factor receptor superfamily, member 9
  • TNFRSF9
  • tnfrsf9a
  • Tnfrsf9
Alternatives
anti-Human CD137 antibody for Enzyme Immunoassay
Reactivity
Human, Non-Human Primate
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Host
Mouse
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Clonality (Clone)
Monoclonal ()
Conjugate
This CD137 antibody is un-conjugated
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Application
Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA
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Options
Supplier
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Supplier Product No.
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Immunogen Recombinant human CD137 ectodomain
Clone 4B4-1
Isotype IgG1
Specificity The mouse monoclonal antibody 4B4-1 recognizes CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
HLDA VI, WS Code C-7
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Alternative Name CD137 / 4-1BB (TNFRSF9 Antibody Abstract)
Background CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Product cited in: Yi, Zhao, Wang, Dai, Hellström, Hellström, Zhang: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, 2014 (PubMed).

Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." in: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, 2012 (PubMed).

Chan, Voskens, Lin, Schindler, Azimzadeh, Wang, Taylor, Strome, Schulze: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." in: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, 2009 (PubMed).

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