SHC2 antibody (SHC (Src Homology 2 Domain Containing) Transforming Protein 2) (Alexa Fluor 594)

Details for Product anti-SHC2 Antibody No. ABIN2806350, Supplier: Log in to see
Antigen
  • SCK
  • SHCB
  • SLI
  • 6720466E06
  • ShcB
  • Sli
  • SHC (Src homology 2 domain containing) transforming protein 2
  • SHC2
  • Shc2
Alternatives
anti-Human SHC2 antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
36
24
23
4
1
Host
Rabbit
31
4
4
Clonality
Polyclonal
Conjugate
This SHC2 antibody is conjugated to Alexa Fluor 594
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
25
12
9
4
4
3
3
1
1
Options
Supplier
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Immunogen KLH conjugated synthetic peptide derived from human SHC2/Sck
Isotype IgG
Purification Purified by Protein A.
Alternative Name SHC2/ Sck (SHC2 Antibody Abstract)
Background

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events (1). Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain (2,3). Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary (4,5). In vascular endothelial cells, Sck participates in VEGF-induced signal transduction (6). Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (KDR) and enhances Sck tyrosine phosphorylation (7,8).

Synonyms: Protein Sck, SCK, SH2 domain protein C2, SHC transforming protein 2, SHCB, Src homology 2 domain containing transforming protein C2, SHC2_HUMAN.

Pathways RTK Signaling, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, VEGF Signaling
Application Notes IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 4°C
Expiry Date 12 months
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