CD3 antibody (CD3)

Details for Product anti-CD3 Antibody No. ABIN284223, Supplier: Log in to see
Antigen
  • CD3
  • CD3d molecule, delta (CD3-TCR complex)
  • CD3e molecule, epsilon (CD3-TCR complex)
  • DNA segment, Chr 9, MRC UK Mouse Genome Centre 45 expressed
  • CD3D
  • CD3E
  • D9Mgc45e
Reactivity
Human
795
281
82
43
40
33
30
16
15
14
13
11
10
8
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
3
2
1
1
Host
Mouse
888
179
62
43
22
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CD3 antibody is un-conjugated
158
120
93
65
30
23
22
21
21
20
16
15
13
12
12
11
8
8
8
8
8
8
7
7
6
5
5
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
953
260
212
150
126
123
111
110
77
48
19
18
16
12
11
10
10
7
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen CD3 antibody was raised in mouse using the epsilon chain of CD3/T-cell antigen receptor complex as the immunogen.
Clone UCHT1
Isotype IgG1
Alternative Name CD3 (CD3 Antibody Abstract)
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Application Notes Optimal conditions should be determined byt he investigator.
Restrictions For Research Use only
Concentration Lot specific
Buffer 100 mM borate buffered saline, pH 8.2
Storage 4 °C
Background publications Rieux-Laucat, Hivroz, Lim, Mateo, Pellier, Selz, Fischer, Le Deist: "Inherited and somatic CD3zeta mutations in a patient with T-cell deficiency." in: The New England journal of medicine, Vol. 354, Issue 18, pp. 1913-21, 2006 (PubMed).

Lin, Liu, Chen, Wang, Medeiros, Hsu: "CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features." in: Blood, Vol. 106, Issue 10, pp. 3567-74, 2005 (PubMed).

Demedts, Brusselle, Vermaelen, Pauwels: "Identification and characterization of human pulmonary dendritic cells." in: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, 2005 (PubMed).

Arnett, Harrison, Wiley: "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 46, pp. 16268-73, 2004 (PubMed).

Torres, Alcover, Zapata, Arnaud, Pacheco, Martín-Fernández, Villasevil, Sanal, Regueiro: "TCR dynamics in human mature T lymphocytes lacking CD3 gamma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 12, pp. 5947-55, 2003 (PubMed).

le Gouvello, Manceau, Sobel: "Serine 16 of stathmin as a cytosolic target for Ca2+/calmodulin-dependent kinase II after CD2 triggering of human T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 3, pp. 1113-22, 1998 (PubMed).

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