This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This SENP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-35 amino acids from the N-terminal region of human SENP8.
den1 antibody, nedp1 antibody, prsc2 antibody, MGC84956 antibody, F15L12.8 antibody, F15L12_8 antibody, 9130010J17Rik antibody, AU020827 antibody, Den1 antibody, Nedp1 antibody, Prsc2 antibody, DEN1 antibody, NEDP1 antibody, PRSC2 antibody, SUMO/sentrin peptidase family member, NEDD8 specific L homeolog antibody, Cysteine proteinases superfamily protein antibody, SUMO/sentrin specific peptidase 8 antibody, SUMO/sentrin peptidase family member, NEDD8 specific antibody, senp8.L antibody, AT5G60190 antibody, Senp8 antibody, SENP8 antibody
Background
NEDD8 is a ubiquitin-like protein that becomes conjugated to the cullin subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. SENP8 is a protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.