SLC7A5 antibody

Catalog No. ABIN289955

Product Details anti-SLC7A5 Antibody

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SLC7A5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: The spleen cells from mouse, immunized with the synthesized peptide of human C endof LAT-1, were fused with mouse P3U1 myeloma cells. The hybridoma cell line withpositive reaction was grown in ascitic fluid of BALB/c mouse, from which theantibody was purified by Peptide affinity chromatography.

Immunogen: Partial peptide of Human L-type Amino Acid Transporter 1 (LAT1)

Clone: 4D9

Isotype: IgM

Application Details

Application Notes: Working dilution for immunohistochemistry: 2-5ug/mlFor more detail on the immunohistochemistry, refer to the immuno staining method.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/ml

Buffer: PBS (containing 0.1% BSA as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for SLC7A5

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Alternative Name: L-type Amino Acid Transporter 1 (LAT1) (SLC7A5 Products)

Synonyms: 4F2LC antibody, CD98 antibody, D16S469E antibody, E16 antibody, LAT1 antibody, MPE16 antibody, hLAT1 antibody, D0H16S474E antibody, TA1 antibody, JHI-21 antibody, SLC7A5 antibody, LAT-1 antibody, slc7a5a antibody, 4F2 antibody, 4F2HC antibody, AI314110 antibody, Cd98 antibody, Ly-10 antibody, Ly-m10 antibody, Ly10 antibody, Mdu1 antibody, Mgp-2hc antibody, NACAE antibody, solute carrier family 7 member 5 antibody, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 antibody, solute carrier family 7 (amino acid transporter light chain, L system), member 5 antibody, solute carrier family 7 member 5 S homeolog antibody, solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 antibody, SLC7A5 antibody, Slc7a5 antibody, slc7a5.S antibody, Slc3a2 antibody

Background: Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection ofamino acid molecule variety, and is clessfied into various transport systems by the transportative substrateselectivity and the Na+ dependence with the reflection of amino acid molecule variety.L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is unique because itrequires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for its functionalexpression. L-type is Na+ -independent neutral amino acid transporter agency and essential for the transporter oflarge neutral amino acid such as Leucine, Isoleucine, Varine through the plasma membrane. LAT1 is, thustransporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-relateddrugs such as L-DOPA. LAT has been proposed to be one of the major nutrient transport systems at theblood-brain barrier. Highly regulated nature and high level of expression in tumor cell lines, LAT is thought to beup-regulated to support the high protein synthesis for cell glowth and cell activation.This antibody has been proved to be useful for the immunohistochemistry.