The galectins are a family of carbohydrate-binding proteins that are distributed widely inmetazoan organisms. Many galectin family members are detected primarily intracellularly inmost of the systems studied, although certain members can be found both inside and outsideof cells. Galectin-3 interacts with beta-galactoside residues of several cell surface and matrixglycoproteins through the carbohydrate recognition domain and is also capable of peptide-peptide associations mediated by its N-terminus domain. Recently, it has beendemonstrated that galectin-3 is a new member of AGEs-receptor complex. (Mol.Med.1:634-646,1995). This antibody is affinity purified rabbit polyclonal antibody raised against recombinant human galectin-3 and should be used for western blotting.