O3FAR1 antibody

Catalog No. ABIN290065

Product Details anti-O3FAR1 Antibody

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This O3FAR1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: Protein G

Immunogen: Partial peptide of Human GPR120

Clone: 2B6

Isotype: IgG2a kappa

Application Details

Application Notes: WB Not tested. IHC Not tested. ICC Not tested. ELISA Not tested. FCM 1.0-5.0 ug/ml. Neutralization Not tested. IP Not tested

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for O3FAR1

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Alternative Name: GPR120 (O3FAR1 Products)

Synonyms: BMIQ10 antibody, GPR120 antibody, GPR129 antibody, GT01 antibody, O3FAR1 antibody, PGR4 antibody, AI552415 antibody, Gpr120 antibody, Gpr129 antibody, KPG_013 antibody, O3far1 antibody, Pgr4 antibody, free fatty acid receptor 4 antibody, phosphodiesterase 6C antibody, FFAR4 antibody, Ffar4 antibody, PDE6C antibody

Background: GPR120 is a member of G protein-coupled receptor (GPCR) family and functions as a specific receptor for unsaturated long-chain free fatty acids (FFAs) such aspalmitoleic acid, alpha-linolenic acid, docosahexaenoic acid. The expression of GPR120 is widely detected in various tissues, and GPR120 is highly expressed in th epituitary, lung, small intestine, colon, and adipose tissues.It has been shown that the stimulation of GPR120 by FFAs promotes the secretion of GLP-1, known as the most potent insulinotropic incretin, from the gastrointestinal tract. It has been also demonstrated that FFAs stimulate the ERK and PI3K-Akt pathways through GPR120 and lead to anti-apoptotic effect in enteroendocrine cell line, and that GPR120 regulates adipogenic process such as adipocyte development and differentiation. In addition, a study suggested that GPR120 is expressed in the taste bud cells in circumvallate papillae to sense dietary fat.This antibody is specific to GPR120 and will be useful for research on diabetes, obesity.

Pathways: Hormone Transport