COPS5 antibody

Catalog No. ABIN302286

The Mouse Monoclonal anti-COPS5 antibody (Clone 6C3-38) (ABIN302286) specifically detects COPS5 in WB, IP and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for COPS5 antibody (ABIN302286)

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6C3-38

Product Details anti-COPS5 Antibody

Specificity: This antibody detects 38 Kda Mov34 Isologue (COPS5).

Characteristics: Synonyms: Signalosome subunit 5, SGN5, CSN5, JAB1, COP9 signalosome complex subunit 5, Junactivation domain-binding protein 1

Purification: Protein G chromatography

Immunogen: Recombinant full-length mouse JAB-1 gene expressed in E. coli

Isotype: IgG2a

Application Details

Application Notes: Immunoprecipitation. Western blot. Immunohistochemistry on paraffin sections (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C to -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: COPS5

Background: JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.Synonyms: COP9 signalosome complex subunit 5, CSN5, JAB1, Jun activation domain-binding protein 1, SGN5, Signalosome subunit 5

Gene ID: 10987

UniProt: Q92905

Pathways: Cell Division Cycle