COPS5 antibody (AA 8-334)

Catalog No. ABIN3042754

Product Details anti-COPS5 Antibody

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Binding Specificity: AA 8-334

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for COP9 signalosome complex subunit 5(COPS5) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for COP9 signalosome complex subunit 5(COPS5) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: COP9 signalosome subunit 5
Protein Name: COP9 signalosome complex subunit 5

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human JAB1 recombinant protein (Position: M8-S334). Human JAB1 shares 99.4% amino acid (aa) sequence identity with mouse JAB1.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: COPS5 (COPS5 Products)

Synonyms: BcDNA.LD14392 antibody, BcDNA:LD14392 antibody, CG14884 antibody, CH5 antibody, CSN-5 antibody, Csn5 antibody, DCH5 antibody, Dch5 antibody, Dmel\\CG14884 antibody, JAB1 antibody, JAB1/CSN5 antibody, Jab1 antibody, JadBp antibody, csn5 antibody, dch5 antibody, jab1/csn5 antibody, l(3)89Cf antibody, l(3)L4032 antibody, l(3)M203 antibody, quo antibody, COPS5 antibody, MGC76063 antibody, AI303502 antibody, CSN5 antibody, Mov34 antibody, Sgn5 antibody, zgc:73130 antibody, MOV-34 antibody, SGN5 antibody, COP9 signalosome subunit 5 antibody, COP9 signalosome complex subunit 5 antibody, COP9 signalosome subunit 5 S homeolog antibody, CSN5 antibody, COPS5 antibody, cops5 antibody, CpipJ_CPIJ012314 antibody, Bm1_46585 antibody, VDBG_06932 antibody, LOAG_01443 antibody, csn5 antibody, Cops5 antibody, cops5.S antibody, csn-5 antibody

Background: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.

Synonyms: 38 kDa Mov34 homolog antibody|COP9 (constitutive photomorphogenic) homolog subunit 5 antibody|COP9 constitutive photomorphogenic homolog subunit 5 antibody|COP9 signalosome complex subunit 5 antibody|COP9 signalosome subunit 5 antibody|Cop9 subunit 5 antibody|COPS 5 antibody|COPS5 antibody|CSN 5 antibody|CSN5 antibody|JAB 1 antibody|Jun activation domain binding protein 1 antibody|Jun activation domain binding protein antibody|Jun activation domain-binding protein 1 antibody|Jun activation domain-binding protein antibody|MGC3149 antibody|MOV 34 antibody|MOV34 antibody|MOV34 family, 38-KD member antibody|SGN 5 antibody|SGN5 antibody|Signalosome subunit 5 antibody

Gene ID: 10987

UniProt: Q92905

Pathways: Cell Division Cycle