ANP32E
Reactivity: Human
IF (cc), IF (p)
Host: Rabbit
Polyclonal
AbBy Fluor® 594
Application Notes
Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Western Blot (0.5-2 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
LANP-L antibody, LANPL antibody, ANP32E antibody, wu:fb22e03 antibody, wu:fc04c12 antibody, wu:fc19a08 antibody, wu:fc79f04 antibody, wu:fi39c10 antibody, zgc:65995 antibody, zgc:85827 antibody, DKFZp459A0729 antibody, 2810018A15Rik antibody, AI047746 antibody, AI326868 antibody, CPD1 antibody, mLANP-L antibody, MGC180507 antibody, acidic nuclear phosphoprotein 32 family member E antibody, acidic (leucine-rich) nuclear phosphoprotein 32 family, member E antibody, acidic nuclear phosphoprotein 32 family member E L homeolog antibody, acidic leucine-rich nuclear phosphoprotein 32 family member E-like antibody, ANP32E antibody, anp32e antibody, Anp32e antibody, anp32e.L antibody, LOC100349957 antibody, LOC100355663 antibody
Background
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-L, LANP-like protein, LANPL, PHAP III