Serotonin Receptor 1A antibody (C-Term)

Catalog No. ABIN3032544

Product Details anti-Serotonin Receptor 1A Antibody

Target: Serotonin Receptor 1A (HTR1A)

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human 5HT1A Receptor(NKDFQNAFKKIIKCKFCRQ) was used as the immunogen for this 5HT1A Receptor antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the 5HT1A Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the 5HT1A Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: 5HT1A Receptor (HTR1A Products)

Synonyms: 5-HT-dro2A antibody, 5-HT1ADro antibody, 5-HT[1A]Dro antibody, 5-HT[[1ADro]] antibody, 5-HT[[1A]] antibody, 5-HT[[1A]]DRO antibody, 5HT-R2A antibody, 5HT-dro2A antibody, 5HT-drp[[2A]] antibody, 5HT1A antibody, 5HT[[1ADro]] antibody, 5htdro2a antibody, CG16720 antibody, DRO2A antibody, Dm5HTdro2A antibody, Dmel\\CG16720 antibody, d5-HT1A antibody, 5htr1a antibody, htr1a antibody, HTR1A antibody, Htr1a antibody, 5-Ht1a antibody, Gpcr18 antibody, 5-HT-1A antibody, 5-HT1A antibody, 5HT1a antibody, ADRB2RL1 antibody, ADRBRL1 antibody, G-21 antibody, PFMCD antibody, RAT5HT1A antibody, 5ht1a antibody, adrb2rl1 antibody, adrbrl1 antibody, htr1a-A antibody, 5-hydroxytryptamine (serotonin) receptor 1A antibody, 5-hydroxytryptamine receptor 1A antibody, 5-hydroxytryptamine (serotonin) receptor 1A a antibody, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog antibody, 5-HT1A antibody, HTR1A antibody, htr1aa antibody, Htr1a antibody, htr1a.L antibody

Background: 5HT1AR is a subtype of 5HTR that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. The HTR1A gene is located at 5q12.3. The decreases in 5HT1AR densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5HT1ARs has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. In the dorsal raphe nucleus they are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

UniProt: P08908

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour