Peroxiredoxin 2 antibody (C-Term)

Catalog No. ABIN3043026

Product Details anti-Peroxiredoxin 2 Antibody

Target: Peroxiredoxin 2 (PRDX2)

Binding Specificity: AA 181-198, C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Peroxiredoxin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Peroxiredoxin-2(PRDX2) detection. Tested with WB in Human,Mouse,Rat.

Sequence: DTIKPNVDDS KEYFSKHN

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Peroxiredoxin-2(PRDX2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: peroxiredoxin 2
Protein Name: Peroxiredoxin-2

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2(181-198aa DTIKPNVDDSKEYFSKHN), identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

References for anti-Peroxiredoxin 2 antibody (ABIN3043026)

You, Zhang, Li, Li, Li, Li, Zhu, Peng, Sun: "Cloning and molecular characterization of phospholipase D (PLD) delta gene from longan (Dimocarpus longan Lour.)." in: Molecular biology reports, Vol. 41, Issue 7, pp. 4351-60, (2014) (PubMed).

Target Details for Peroxiredoxin 2

Target: Peroxiredoxin 2 (PRDX2)

Alternative Name: PRDX2 (PRDX2 Products)

Synonyms: NKEF-B antibody, NKEFB antibody, PRP antibody, PRX2 antibody, PRXII antibody, PTX1 antibody, TDPX1 antibody, TPX1 antibody, TSA antibody, AL022839 antibody, Band-8 antibody, NkefB antibody, PrxII antibody, TDX1 antibody, TPx antibody, TPx-B antibody, TR antibody, Tdpx1 antibody, Torin antibody, nkefb antibody, prx-2 antibody, prx2 antibody, prxii antibody, tdpx1 antibody, tpx1 antibody, peroxiredoxin 2 antibody, peroxiredoxin 2 L homeolog antibody, PRDX2 antibody, Prdx2 antibody, prdx2.L antibody

Background: PRDX2(peroxiredoxin 2) also known as NKEFB, PRP, PRX2, PRXII or TPX1, is a protein that in humans is encoded by the PRDX2 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The Prdx2 -/- mice were healthy in appearance and fertile. Choi et al.(2005) demonstrated that PRDX2 is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRX2 accounted for about half of the thioredoxin activity in parasite extracts, and PRX2 expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug.

Synonyms: MGC4104 antibody|Natural killer cell enhancing factor B antibody|Natural killer cell-enhancing factor B antibody|Natural Killer Enhancing Factor B antibody|NKEF B antibody|NKEF-B antibody|NKEFB antibody|Peroxiredoxin-2 antibody|PRDX 2 antibody|PRDX2 antibody|PRDX2_HUMAN antibody|PrP antibody|PRX2 antibody|PRXII antibody|TDPX1 antibody|Thiol Specific Antioxidant 1 antibody|Thiol specific antioxidant protein antibody|Thiol-specific antioxidant protein antibody|Thioredoxin Dependent Peroxide Reductase 1 antibody|Thioredoxin peroxidase 1 antibody|Thioredoxin-dependent peroxide reductase 1 antibody|Torin antibody|TPX1 antibody|TSA antibody

UniProt: P32119