TIMP2 antibody (AA 27-220)
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- Target See all TIMP2 Antibodies
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
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Binding Specificity
- AA 27-220
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TIMP2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with WB in Human,Mouse,Rat.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: TIMP metallopeptidase inhibitor 2
Protein Name: Metalloproteinase inhibitor 2 - Purification
- Immunogen affinity purified.
- Immunogen
- E. coli-derived human TIMP2 recombinant protein (Position: C27-P220). Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse and rat TIMP2.
- Isotype
- IgG
- Top Product
- Discover our top product TIMP2 Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).
: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats." in: Bioengineered, Vol. 7, Issue 5, pp. 314-320, (2017) (PubMed).
: "Erratum: Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway ..." in: International journal of nanomedicine, Vol. 12, pp. 1515, (2017) (PubMed).
: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).
: "Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers." in: Journal of ophthalmology, Vol. 2016, pp. 4952340, (2016) (PubMed).
: "Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120178, (2015) (PubMed).
: "MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 56-63, (2014) (PubMed).
: "The effect of 2,3,4',5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms." in: European journal of pharmacology, Vol. 698, Issue 1-3, pp. 370-8, (2013) (PubMed).
: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).
: "Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats." in: Molecular biology reports, Vol. 40, Issue 2, pp. 1429-41, (2013) (PubMed).
: "Expression of both matrix metalloproteinase-2 and its tissue inhibitor-2 in tunica media of radial artery in uremic patients." in: Renal failure, Vol. 35, Issue 1, pp. 37-42, (2013) (PubMed).
: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).
: "Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats." in: Toxicology, Vol. 285, Issue 1-2, pp. 31-8, (2011) (PubMed).
: "Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 9, Issue 4, pp. 414-22, (2011) (PubMed).
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The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).
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- Target
- TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))
- Alternative Name
- TIMP2 (TIMP2 Products)
- Synonyms
- CSC-21K antibody, DDC8 antibody, timp2l antibody, zgc:65967 antibody, zgc:85799 antibody, D11Bwg1104e antibody, Timp-2 antibody, TIMP-2 antibody, etID32613.12 antibody, fa96h09 antibody, timp2 antibody, wu:fa96h09 antibody, zgc:136726 antibody, TIMP metallopeptidase inhibitor 2 antibody, TIMP metallopeptidase inhibitor 2b antibody, tissue inhibitor of metalloproteinase 2 antibody, TIMP metallopeptidase inhibitor 2a antibody, TIMP metallopeptidase inhibitor 2 L homeolog antibody, TIMP2 antibody, timp2b antibody, Timp2 antibody, timp2a antibody, timp2.L antibody
- Background
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TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Synonyms: CSC 21K antibody|CSC-21K antibody|CSC21K antibody|Metalloproteinase inhibitor 2 antibody|Metalloproteinase inhibitor 2 precursor antibody|TIMP 2 antibody|TIMP metallopeptidase inhibitor 2 antibody|TIMP-2 antibody|TIMP2 antibody|TIMP2_HUMAN antibody|Tissue Inhibitor of Metalloproteinase 2 antibody|Tissue inhibitor of metalloproteinases 2 antibody - Gene ID
- 7077
- UniProt
- P16035
- Pathways
- cAMP Metabolic Process
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