PER2 antibody (AA 13-330)

Catalog No. ABIN3043602

Product Details anti-PER2 Antibody

Target: PER2 (Period Circadian Protein 2 (PER2))

Binding Specificity: AA 13-330

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PER2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Period circadian protein homolog 2(PER2) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Period circadian protein homolog 2(PER2) detection. Tested with WB in Human.
Gene Name: period circadian clock 2
Protein Name: Period circadian protein homolog 2

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for PER2 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Alternative Name: PER2 (PER2 Products)

Synonyms: FASPS antibody, FASPS1 antibody, mKIAA0347 antibody, mPer2 antibody, rPER2 antibody, gPer2 antibody, fj43b09 antibody, wu:fj43b09 antibody, period circadian regulator 2 antibody, period circadian clock 2 antibody, PER2 antibody, Per2 antibody, per2 antibody

Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Synonyms: Circadian clock protein PERIOD 2 antibody|FASPS antibody|FASPS1 antibody|hPER 2 antibody|hPER2 antibody|KIAA0347 antibody|OTTHUMP00000164476 antibody|PER 2 antibody|PER2 antibody|PER2_HUMAN antibody|Period 2 antibody|Period 2 isoform 1 antibody|Period circadian clock 2 antibody|Period circadian protein 2 antibody|Period circadian protein homolog 2 antibody|Period homolog 2 (Drosophila) antibody|Period homolog 2 antibody|Period2 antibody

Gene ID: 8864

UniProt: O15055