MALT1 antibody (C-Term)

Catalog No. ABIN3044126

Product Details anti-MALT1 Antibody

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Binding Specificity: AA 809-824, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MALT1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MALT1) detection. Tested with WB in Human.

Sequence: DEIPFSFSDR LRISEK

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MALT1) detection. Tested with WB in Human.
Gene Name: mucosa associated lymphoid tissue lymphoma translocation gene 1
Protein Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MALT1(809-824aa DEIPFSFSDRLRISEK).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MALT1 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MALT1

Target: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Alternative Name: MALT1 (MALT1 Products)

Synonyms: malt1 antibody, MALT1 antibody, mlt antibody, mlt1 antibody, MLT antibody, MLT1 antibody, A630046N12 antibody, D430033E09Rik antibody, MALT paracaspase 2 antibody, MALT1 paracaspase antibody, MALT1 paracaspase S homeolog antibody, paracaspase 3 antibody, malt2 antibody, MALT1 antibody, malt1.S antibody, Malt1 antibody, PCASP3 antibody

Background: MALT1(Mucosa-associated lymphoid tissue lymphoma translocation protein 1), also called MLT or PARACASPASE, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al.(1999) and Akagi et al.(1999) mapped the MALT1 gene to chromosome 18q21. Using mouse models, Ruland et al.(2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.

Synonyms: Caspase like protein antibody|DKFZp434L132 antibody|MALT 1 antibody|MALT associated translocation antibody|MALT lymphoma associated translocation antibody|MALT lymphoma-associated translocation antibody|Malt1 antibody|MALT1_HUMAN antibody|MLT 1 antibody|MLT antibody|MLT1 antibody|Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody|Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody|Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody|Paracaspase antibody

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins