S1PR5 antibody

Catalog No. ABIN306731

The Rabbit Polyclonal anti-S1PR5 antibody is suitable to detect S1PR5 in samples from Human. It has been validated for WB.

Quick Overview for S1PR5 antibody (ABIN306731)

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-S1PR5 Antibody

Purpose: Rabbit anti Human Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)

Cross-Reactivity: Human

Characteristics: Endothelial Cell Differentiation Gene-8 (EDG-8) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-8 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-8 is expressed in oligodendrocytes and fibrous astrocytes in the rat brain.

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Application Details

Application Notes: Detects recombinant EDG8 receptors by Western blot (5-10 μg/mL) at 42 kDa. Due to low expression of EDG receptors, we recommend use of Pierce Femto Signal substrate for western blot development. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for S1PR5

Target: S1PR5 (Sphingosine-1-Phosphate Receptor 5 (S1PR5))

Alternative Name: Sphingosine 1 Phosphate Receptor 5 CT (EDG-8)

Background: Endothelial Cell Differentiation Gene-8 Receptor C-Terminal

UniProt: Q9H228